3.1.4.4.1.1.2. Coagulation cascade  
 
A.1.3. Coagulation cascade
    - Conversion of plug into definitive clot is by formation of insoluble fibrin from soluble plasma protein fibrinogen
 
    - Fibrin initially is a loose mesh of interlacing strands
 
    - Stabilisation is when this loose mesh is converted to a tight and dense aggregate via formation of covalent cross-linkages